Uterine Smooth Muscle S-Nitrosylproteome in Pregnancy
نویسندگان
چکیده
منابع مشابه
Uterine smooth muscle S-nitrosylproteome in pregnancy.
The molecular mechanisms involved in uterine quiescence during gestation and those responsible for induction of labor are not completely known. Nitric oxide relaxes uterine smooth muscle in a manner disparate from that for other smooth muscles because global elevation of cGMP after activation of soluble guanylyl cyclase does not relax the muscle. S-Nitrosylation, the covalent addition of an nit...
متن کاملThe human uterine smooth muscle S-nitrosoproteome fingerprint in pregnancy, labor, and preterm labor.
Molecular mechanisms involved in uterine quiescence during gestation and those responsible for induction of labor at term are incompletely known. More than 10% of babies born worldwide are premature and 1,000,000 die annually. Preterm labor results in preterm delivery in 50% of cases in the United States explaining 75% of fetal morbidity and mortality. There is no Food and Drug Administration-a...
متن کاملLC/MS/MS data analysis of the human uterine smooth muscle S-nitrosoproteome fingerprint in pregnancy, labor, and preterm labor
The data described in this article is the subject of an article in the American Journal of Physiology: Cell Physiology, titled "The Human Uterine Smooth Muscle S-nitrosoproteome Fingerprint in Pregnancy, Labor, and Preterm Labor" (doi:10.1152/ajpcell.00198.2013) (Ulrich et al., 2013) [1]. The data described is a large scale mass spectrometry data set that defines the human uterine smooth muscle...
متن کاملCalcium diffusion in uterine smooth muscle sheets
The potassium contracture in the longitudinal muscle of estrogen-treated rat uterus was kinetically investigated. The rates of tension development after Ca addition and relaxation after Ca removal were measured under the high-potassium depolarization. Both rates decreased with an increase in preparation thickness. The relaxation rate had only a slight dependence on temperature. On the contrary,...
متن کاملPregnancy increases ET-1-induced contraction and changes receptor subtypes in uterine smooth muscle in humans.
The purpose of the present study was to investigate whether pregnancy affects endothelin (ET)-1-induced contraction, the density ofET receptors, and the ratio of receptor subtypes (ET(A) and ET(B)) in uterine smooth muscle in humans. We also investigated which ET receptor subtypes mediate ET-1-induced contraction in the human uterus. In uterine membrane preparations, (125)I-labeled ET-1 ((125)I...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2011
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.111.075804